… they allow us to study both VSMC origin and fate, including the … our understanding of their
role in atherosclerosis (Figure 2). … -like cell is likely driven by lipid accumulation, as cholesterol …

… heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for
… potential applications in atherosclerosis such as reduction of cholesterol levels. The most …

… focus on the origin of foam cells with lipids … cells containing crystalline substances have
phagocytic activity in PCSK9-induced murine atherosclerotic plaque, similar to cholesterol-crystal…

… The origin and fate of mesenchymal- like cells in atherosclerotic plaques is unclear… smooth
muscle cells to cholesterol accumulation and macrophage- like cells in human atherosclerosis…

… regulating cholesterol crystal formation, shape, size, and origin. BF, bright field; CC, … in
smooth muscle cells 12 and aortic endothelial cells 13 (Figure 2D–F), two additional important cell …

… in the aortic media of the Perk SMC−/− mice does not lead to cholesterol crystal deposits
and necrotic areas, or to an influx of macrophages into the medial layer. Finally, Perk deficiency …

… The patients were classified into two groups according to whether they had a history of DM.
… ox-LDL group and a large number of cholesterol crystals were visible under the fibrous cap. …

… smooth muscle cells (VSMCs) of mice promotes vascular inflammation and accelerates the
occurrence and progression of atherosclerosis. We … The crystalline form of cholesterol that is …

… + cells of SMC origin was verified in plaques from MYH11 lineage-tracing atherosclerotic …
from mouse model of atherosclerosis regression and plasma cholesterol lowering, where Ldlr −/…

… into endothelial cells (ECs) and vascular smooth muscle cells (… the exact cells in which
AADAC is acting to alter atherogenesis. … Cholesterol crystal detection The atherosclerotic lesions …